Studies conducted with ZIRP infrastructure & team members


Seebeck P. 'We have to talk about rodent surgery!' - one day symposium, 12 June 2022 in Marseille, France. Lab Anim. 2022 Oct;56(5):493-494. doi: 10.1177/00236772221125682. PMID: 36255246.

Gantenbein F, Buchholz T, Wever KE, Ritskes Hoitinga M, Zeiter S, Seebeck P. Protocol for a systematic review of good surgical practice guidelines for experimental rodent surgery. BMJ Open Sci. 2022 Sep 5;6(1):e100280. doi: 10.1136/bmjos-2022-100280. PMID: 36387951; PMCID: PMC9644723.

Brilkova M, Nigri M, Kumar HS, Moore J, Mantovani M, Keller C, Grimm A, Eckert A, Shcherbakov D, Akbergenov R, Seebeck P, Krämer SD, Wolfer DP, Gent TC, Böttger EC. Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice. Cell Rep. 2022 Sep 27;40(13):111433. doi: 10.1016/j.celrep.2022.111433. PMID: 36170830.

Cuomo-Haymour N, Sigrist H, Ineichen C, Russo G, Nüesch U, Gantenbein F, Kulic L, Knuesel I, Bergamini G, Pryce CR. Evidence for Effects of Extracellular Vesicles on Physical, Inflammatory, Transcriptome and Reward Behaviour Status in Mice. Int J Mol Sci. 2022 Jan 18;23(3):1028. doi: 10.3390/ijms23031028. PMID: 35162951; PMCID: PMC8835024.

Dahl SL, Pfundstein S, Hunkeler R, Dong X, Knöpfel T, Spielmann P, Scholz CC, Nolan KA, Wenger RH. Fate-mapping of erythropoietin-producing cells in mouse models of hypoxaemia and renal tissue remodelling reveals repeated recruitment and persistent functionality. Acta Physiol (Oxf). 2022 Mar;234(3):e13768. doi: 10.1111/apha.13768. Epub 2022 Jan 16. PMID: 34982511

Ruiz-Serrano A, Boyle CN, Monné Rodríguez JM, Günter J, Jucht AE, Pfundstein S, Bapst AM, Lutz TA, Wenger RH, Scholz CC. The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism. Int J Mol Sci. 2022 Jan 28;23(3):1536. doi: 10.3390/ijms23031536. PMID: 35163456; PMCID: PMC8836018.

Shcherbakov D, Nigri M, Akbergenov R, Brilkova M, Mantovani M, Petit PI, Grimm A, Karol  AA, Teo Y, Sanchón AC, Kumar Y, Eckert A, Thiam K, Seebeck P, Wolfer DP, Böttger EC. Premature aging in mice with error-prone protein synthesis. Sci Adv. 2022 Mar 4;8(9):eabl9051. doi: 10.1126/sciadv.abl9051. Epub 2022 Mar 2. PMID: 35235349.


Flürenbrock F, Schwander S, Podgoršak A, Bausch B, Seebeck P, Zeilinger M, Schmid Daners M. Insights of posture dependent pressure characteristics in five rats October 2021 Current Directions in Biomedical Engineering 2021 Oct 7(2):799-802 doi: 10.1515/cdbme 2021-2204.

Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS. Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2106770118. doi: 10.1073/pnas.2106770118. PMID: 34548398; PMCID: PMC8488674.

Kast F, Schwill M, Stüber JC, Pfundstein S, Nagy-Davidescu G, Rodríguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Plückthun A. Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nat Commun. 2021 Jun 18;12(1):3790. doi: 10.1038/s41467-021-23948-6. PMID: 34145240; PMCID: PMC8213836.

Moore J, Akbergenov R, Nigri M, Isnard-Petit P, Grimm A, Seebeck P, Restelli L, Frank S,  Eckert A, Thiam K, Wolfer DP, Shcherbakov D, Böttger EC. Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice. Commun Biol. 2021 Jun 8;4(1):703. doi: 10.1038/s42003-021-02204-z.

Ruiz-Serrano A, Monné Rodríguez JM, Günter J, Sherman SPM, Jucht AE, Fluechter P, Volkova YL, Pfundstein S, Pellegrini G, Wagner CA, Schneider C, Wenger RH, Scholz CC. OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control. FASEB J. 2021 Dec;35(12):e22039. doi: 10.1096/fj.202100346R. PMID: 34793600.


Gomes de Almeida Schirmer B, Crucet M, Stivala S, Vucicevic G, Silva Barcelos L, Vanhouttec PM, Pellegrini G, Camici GG, Seebeck P, Pfundstein S, Stein S, Paneni F, Lüscher TF, Simic B. The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF[1]1α. Atherosclerosis. 2020 Jul;304:30-38. doi: 10.1016/j.atherosclerosis.2020.05.012.


Daryadel A, Natale L, Seebeck P, Bettoni C, Schnitzbauer U, Gassmann M, Wagner CA. Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice. Sci Rep. 2019 Oct 18;9(1):14989. doi: 10.1038/s41598-019-51577-z.

Imeri F, Nolan KA, Bapst AM, Santambrogio S, Abreu-Rodríguez I, Spielmann P, Pfundstein S, Libertini S, Crowther L, Orlando IMC, Dahl SL, Keodara A, Kuo W, Kurtcuoglu V, Scholz CC, Qi W, Hummler E, Hoogewijs D, Wenger RH. Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype. Kidney Int. 2019 Feb;95(2):375-387. doi: 10.1016/j.kint.2018.08.043. Epub 2018 Nov 27. PMID: 30502050.

Jirkof P, Seebeck P. Vital signs without handling or animal prep. Lab Anim (NY). 2019 May; 48(5):144-145. doi: 10.1038/s41684-019-0290-1.

Pillai SM, Herzog B, Seebeck P, Pellegrini G, Roth E, Verrey F. Differential Impact of Dietary Branched Chain and Aromatic Amino Acids on Chronic Kidney Disease Progression in Rats. Front Physiol. 2019 Dec 9;10:1460. doi: 10.3389/fphys.2019.01460. eCollection 2019.

Stellato M, Rudnik M, Renoux F, Blyszczuk P,Osto E, Dewenter M, Seebeck P, Pachera E, Distler O, Kania G. LIN-GP38+ stromal cells are key effector cells in myocardial fibrosis and defects of the conduction system. Annals of the Rheumatic Diseases 2019 June; 78(Suppl 2):168.2-169 doi: 10.1136/annrheumdis-2019-eular.6403


Beffinger M, Tallón de Lara P, Tugues S, Vermeer M, Montagnolo Y, Ohs I, Cecconi V, Lucchiari G, Gagliardi A, Misljencevic N, Sutton J, Spörri R, Becher B, Gupta A, van den Broek M. CSF1R-dependent myeloid cells are required for NKmediated control of metastasis. JCI Insight. 2018 May 17;3(10). pii: 97792. doi: 10.1172/jci.insight.97792. [Epub ahead of print]

Brandt LP, Albers J, Hejhal T, Pfundstein S, Gonçalves AF, Catalano A, Wild PJ, Frew IJ. Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Oncotarget. 2018 Apr 13;9(28):19753-19766. doi: 10.18632/oncotarget.24831. eCollection 2018 Apr

Pillai SM, Seebeck P, Fingerhut R, Huang J, Ming XF, Yang Z, Verrey F. Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice. J Am Heart Assoc. 2018 Feb 25;7(5). pii: e008025. doi: 10.1161/JAHA.117.008025.

Pastor-Arroyo EM, Gehring N, Krudewig C, Costantino S, Bettoni C, Knöpfel T, Sabrautzki S, Lorenz-Depiereux B, Pastor J, Strom TM, Hrabě de Angelis M, Camici GG, Paneni F, Wagner CA, Rubio-Aliaga I. The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk. Kidney Int. 2018 Jul;94(1):49-59. doi: 10.1016/j.kint.2018.02.017. Epub 2018 May 5.


Beck-Schimmer B, Baumann L, Restin T, Eugster P, Hasler M, Booy C, Schläpfer M. Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study. Eur J Anaesthesiol. 2017 Nov;34(11):764-775. doi: 10.1097/EJA.0000000000000668.

Brandt LP, Albers J, Hejhal T, Catalano A, Wild PJ, Frew IJ. Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma. PLoS One. 2017 Oct 5;12(10):e0186102. doi: 10.1371/journal.pone.0186102. eCollection 2017.

Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat Commun. 2017 Jul 24;8(1):98. doi: 10.1038/s41467-017-00213-3.

Gonçalves AF, Adlesic M, Brandt S, Hejhal T, Harlander S, Sommer L, Shakhova O, Wild PJ, Frew IJ. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun. 2017 Nov 13;8(1):1466. doi: 10.1038/s41467-017-01514-3.

Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ. Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice. Nat Med. 2017 Jul;23(7):869-877. doi: 10.1038/nm.4343. Epub 2017 May 29.

Jando, J., Camargo, S.M.R., Herzog, B., Verrey, F. 2017. Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine. PLoS One. 12(9):e0184845.

Knöpfel T, Pastor-Arroyo EM, Schnitzbauer U, Kratschmar DV, Odermatt A, Pellegrini G, Hernando N, Wagner CA. The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction. Sci Rep. 2017 Sep 8;7(1):11018. doi: 10.1038/s41598-017-10390-2.

Restivo G, Diener J, Cheng PF, Kiowski G, Bonalli M, Biedermann T, Reichmann E, Levesque MP, Dummer R, Sommer L. low neurotrophin receptor CD271 regulates phenotype switching in melanoma. Nat Commun. 2017 Dec 7;8(1):1988. doi: 10.1038/s41467-017-01573-6. Erratum in: Nat Commun. 2018 Jan 22;9(1):314.

Schadde E, Hertl M, Breitenstein S, Beck-Schimmer B, Schläpfer M. Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure. J Vis Exp. 2017 Aug 14;(126). doi: 10.3791/55895.

Schadde E, Tsatsaris C, Swiderska-Syn M, Breitenstein S, Urner M, Schimmer R, Booy C, Z'graggen BR, Wenger RH, Spahn DR, Hertl M, Knechtle S, Diehl AM, Schläpfer M, Beck-Schimmer B. Hypoxia of the growing liver accelerates regeneration. Surgery. 2017 Mar;161(3):666-679. doi: 10.1016/j.surg.2016.05.018. Epub 2016 Jul 16.

Tarasco E, Seebeck P, Pfundstein S, Daly AF, Eugster PJ, Harris AG, Grouzmann E, Lutz TA, Boyle CN. Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine. 2017 Oct;58(1):124-133. doi: 10.1007/s12020-017-1386-2. Epub 2017 Aug 18.

Willrodt AH, Beffinger M, Vranova M, Protsyuk D, Schuler K, Jadhav M, Heikenwalder M, van den Broek M, Borsig L, Halin C. Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis. Am J Pathol. 2017 Nov;187(11):2558-2569. doi: 10.1016/j.ajpath.2017.07.008. Epub 2017 Aug 17.


Guinot A, Lehmann H, Wild PJ, Frew IJ. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016 Jul;239(3):365-73. doi: 10.1002/path.4736. Epub 2016 May 30.

Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ. Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α. Cancer Res. 2016 Apr 1;76(7):2025-36. doi: 10.1158/0008-5472.CAN-15-1859. Epub 2016 Jan 12.

Schönenberger D, Rajski M, Harlander S, Frew IJ. Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis. Oncotarget. 2016 Sep 20;7(38):60971-60985. doi: 10.18632/oncotarget.11275.


Drägert K, Bhattacharya I, Pellegrini G, Seebeck P, Azzi A, Brown SA, Georgiopoulou S, Held U, Blyszczuk P, Arras M, Humar R, Hall MN, Battegay E, Haas E. Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure. Hypertension. 2015 Aug;66(2):332-9. doi: 10.1161/HYPERTENSIONAHA.115.05398. Epub 2015 Jun 22.

Lehmann H, Vicari D, Wild PJ, Frew IJ. Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation. J Am Soc Nephrol. 2015 Nov;26(11):2778-88. doi: 10.1681/ASN.2014090875. Epub 2015 Mar 18.

Lelli A, Nolan KA, Santambrogio S, Gonçalves AF, Schönenberger MJ, Guinot A, Frew IJ, Marti HH, Hoogewijs D, Wenger RH. Induction of long noncoding RNA MALAT1 in hypoxic mice. Hypoxia (Auckl). 2015 Oct 8;3:45-52. eCollection 2015.

Mircsof D, Langouët M, Rio M, Moutton S, Siquier-Pernet K, Bole-Feysot C, Cagnard N, Nitschke P, Gaspar L, Žnidarič M, Alibeu O, Fritz AK, Wolfer DP, Schröter A, Bosshard G, Rudin M, Koester C, Crestani F, Seebeck P, Boddaert N, Prescott K; DDD Study, Hines R, Moss SJ, Fritschy JM, Munnich A, Amiel J, Brown SA, Tyagarajan SK, Colleaux L. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci. 2015 Dec;18(12):1731-6. doi: 10.1038/nn.4169. Epub 2015 Nov 16.


Jordi, J., Herzog, B., Lutz, T.A., Verrey, F. 2014. Novel anti-diabetic nutrients identified by in vivo screening for gastric secretion and emptying regulation in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(7):R869-78

Jordi, J., *Verrey, F., *Lutz, T.A. 2014. Simultaneous assessment of gastric emptying and secretion in rats by a novel computed tomography-based method. Am J Physiol Gastrointest Liver Physiol. 306(3):G173-82. (*contributed equally)

Ostergaard L, Rudiger A, Wellmann S, Gammella E, Beck-Schimmer B, Struck J, Maggiorini M, Gassmann M. Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure. Hypoxia (Auckl). 2014 Sep 11;2:143-151. eCollection 2014.


Abegg K, Gehring N, Wagner CA, Liesegang A, Schiesser M, Bueter M, Lutz TA. Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 1;305(9):R999-R1009. doi: 10.1152/ajpregu.00038.2013. Epub 2013 Sep 11.

Albers J, Rajski M, Schönenberger D, Harlander S, Schraml P, von Teichman A, Georgiev S, Wild PJ, Moch H, Krek W, Frew IJ. Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice. EMBO Mol Med. 2013 Jun;5(6):949-64. doi: 10.1002/emmm.201202231. Epub 2013 Apr 22.


Mariotta, L., Ramadan, T., Singer, D., Guetg, A., Herzog, B., Stoeger, C., Palacín, M., Lahoutte, T., Camargo, S.M.R., Verrey, F. 2012. T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control. J Physiol  15;590(Pt 24):6413-24

Simic B, Hermann M, Shaw SG, Bigler L, Stalder U, Dörries C, Besler C, Lüscher TF, Ruschitzka F. Torcetrapib impairs endothelial function in hypertension. Eur Heart J. 2012 Jul;33(13):1615-24. doi: 10.1093/eurheartj/ehr348. Epub 2011 Sep 14.

Singer, D., Camargo, S.M., Ramadan, T., Schäfer, M., Mariotta, L., Herzog, B., Huggel, K., Wolfer, D., Werner, S., Penninger, J.M., Verrey, F. 2012. Defective intestinal amino acid absorption in Ace2 null mice. Am J Physiol Gastrointest Liver Physiol. 303(6):G686-95